Fig. 3

SIRPα-v Exos accelerate the clearance of hematoma and improve long-term prognosis after ICH. A Coronal SWI images of radiological hematoma changes in mice after ICH, assessed by 11.7 T Ultrahigh field magnetic resonance on the 1st, 3rd, and 7th days post-ICH. B Quantification analysis of the hematoma volume on the 1st, 3rd, and 7th days post-ICH. Compared with the Con and NC Exo groups, the clearance of hematoma was markedly accelerated in the SIRPα-v Exo group (n = 12/group). C, D Sensorimotor functions assessed before and 1, 3, 7, 14, and 35 days after ICH or sham surgery. C The foot-fault test. The frequency of the forepaw or hindpaw was quantified (n = 12/group). D The adhesive removal test. The latency of biting or licking to remove the sticker was measured (n = 10/group). E Representative images of swim paths of mice in each group evaluated by the Morris water maze test on the 35th day post-ICH. The yellow circles represent the location where the platform was previously located. F The time spent in the quadrant and frequency of visits to the quadrant of the previously located platform (n = 12/group). * P < 0.05, ** P < 0.01, *** P < 0.001 vs. Sham group; # P < 0.05, ## P < 0.01 vs. Con group; ▲ P < 0.05, vs. NC Exo group; ns, no significance. All the data are presented as the mean ± SD