Fig. 6
From: Recent advances in near-infrared-II hollow nanoplatforms for photothermal-based cancer treatment
Schematic illustration of (a) the fabrication of DSF@PEG-HCuSNPs and (b) the corresponding synergy of NIR-II-induced photonic hyperthermia and the in situ formation of a Cu(DTC)2 complex for augmented chemotherapeutic efficacy of DSF-based chemotherapy. c TEM images and elemental distribution mappings of HCuSNPs. d UV–vis–NIR absorption spectra of varying doses of HCuSNPs (5, 10, 20, 40, and 80 ppm). e UV–vis–NIR absorption spectra of DSF (50 ppm), PEG-HCuSNPs (60 ppm), and DSF@PEG-HCuSNPs (60 ppm). f Heating curves of varying concentrations of DSF@PEG-HCuSNPs upon 1064 nm laser exposure (1 W cm–2). g Photo-to-heat conversion capability of a DSF@PEG-HCuSNPs aqueous dispersion upon 1064 nm laser exposure (1 W cm–2). h Relative cellular survival rates after varied treatments, including control, DSF only, HCuSNPs only, NIR-II laser only, DSF@PEG-HCuSNPs, HCuSNPs + NIR-II laser, and DSF@PEG-HCuSNPs + NIR-II laser groups. i PA images in vivo in tumor tissues after intravenous administration of DSF@PEG-HCuSNPs at varying time intervals. j Tumor inhibition rate and k Body weight of 4T1 tumor-bearing nude mice in the control, NIR-II laser only, DSF only, HCuSNPs only, DSF@PEG-HCuSNPs, HCuSNPs + NIR-II laser, and DSF@PEG-HCuSNPs + NIR-II laser group. Reproduced with permission from Ref. [104]. Copyright 2021, American Chemical Society