Fig. 4

A STEM imaging of AuHNRs-DTPP. B HAADF-STEM imaging and element mapping (using P-K shell, Au-L shell and Au-M shell) of AuHNRs-DTPP. C Ultra-violet and visible (UV-Vis) spectrum of AuHNRs, DTPP and AuHNRs-DTPP. Temperature change of AuHNRs-DTPP in PBS (D) at the concentration of 50 g L^–1 AuHNRs-DTPP with various laser power and (E) under the laser power of 0.69 W cm^–2 with various concentration. F Relative fluorescence intensity changes of AuHNRs-DTPP incubated with recombinant caspase-3. 10 min irradiation with 1064 nm laser (0.69 W cm^–2) was taken as control. G ROS generation of AuHNRs-DTPP (treated with recombinant caspase-3 for 2 h) under light irradiation using 2′-7′-dichlorofluorescin diacetate (DCFH-DA) as the sensor. AuHNRs, PBS and matrix metalloproteinase-2 (MMP-2) were used as controls. H Confocal laser scanning microscopy (CLSM) imaging of intracellular ROS formation under 633 nm laser. I In vivo fluorescence images of tumor-bearing mice after intravenous injection of AuHNRs-DTPP, free DTPP was used as control, 1064 nm laser irradiation was conduct at 8th h. J Relative tumor volume in different groups. Reproduced with permission from Ref. [99]. Copyright 2019, Ivyspring International Publisher