Skip to main content
Fig. 5 | Biomaterials Research

Fig. 5

From: Implantable micro-scale LED device guided photodynamic therapy to potentiate antitumor immunity with mild visible light

Fig. 5

Combination of micro-LED guided PDT and immune checkpoint blocakde. (a) Tumor growth of murine colon tumor models during co-treatment with micro-LED guided PDT and immune checkpoint blockade. (b) Tumor tissues stained with TUNEL on day 14 after treatment. (c) Body weight change during treatment. (d) Mice survival during treatment. (e, f) The population of splenic effector/memory T cells among the CD8+ T cells (CD3+CD8+CD44+CD62Llow) in mice that experienced complete tumor regression (CR) by treatment with 25 mW micro-LED and anti-PD-L1 antibody. (g) Tumor growth and optical images of CR and naive mice rechallenged with CT26 cells. (h) The amount of IFN-γ and IL-6 in the serum after 15 days of tumor rechallenge. Significance was determined by Student’s t test (f-h), log-rank test (d) or Tukey − Kramer posthoc test (a)

Back to article page