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Fig. 4 | Biomaterials Research

Fig. 4

From: Implantable micro-scale LED device guided photodynamic therapy to potentiate antitumor immunity with mild visible light

Fig. 4

Antitumor immunity by micro-LED guided PDT. (a) The population of surface CRT-expressed tumor cells (CD45-CRT+) in the tumor tissues on day 14 after treatment. (b) Relative HMGB1 release from tumor cells to supernatants on day 14 after treatment. (c) Population of mature DCs (CD11c+CD40+CD86+) and cytotoxic T lymphocytes (CTLs; CD45+CD3+CD8+) in the tumor tissues on day 14 after treatment. (d) The amount of IFN-γ in the tumor supernatants on day 14 after treatment. (e) Population of regulatory T lymphocytes (Tregs; CD3+CD4+CD25+) in the tumor tissues on day 14 after treatment. (f) Tumor tissues stained with anti-CD8 or anti-CD25 antibodies on day 14 after treatment. (g) The amount of IL-10 in the tumor supernatants on day 14 after treatment. Significance was determined by Tukey − Kramer posthoc test

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