Fig. 1
From: Targeted thrombolysis by magnetoacoustic particles in photothrombotic stroke model
Schematic fabrication procedure of rmDPPs. (a) The inverse of the Si master template is acquired by pouring the polydimethylsiloxane (PDMS) solution into the master template. (b) A poly(vinyl alcohol (PVA) film with the same structure as the master template is made by pouring PVA solution into the PDMS template. (c) Filling the discoidal wells with a polymer paste obtained from poly(lactic-co-glycolic) acid (PLGA), SPIONs, and rtPA. (d) The hydrophilic layer of the PVA mask is dissolved in water, and (e) flow through membranes with 100 and 1.2 \(\upmu\)m-sized pores is performed to purify the rmDPPs. (f) Schematic illustration of rmDPPs consisting of PLGA, SPIONs, and rtPA in a blood vessel