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Scheme 1 | Biomaterials Research

Scheme 1

From: Oxygen tank for synergistic hypoxia relief to enhance mitochondria-targeted photodynamic therapy

Scheme 1

Schematic illustration of the design, synergistic hypoxia reversal function, and therapeutic functions of the Oxygen Tank. a) Design illustration of the Oxygen Tank. On the one hand, the biomimetic coating of the Oxygen Tank is similar to the stealth coating of a battle tank; On the other hand, the Oxygen Tank opened source and reduced the expenditure of oxygen as a gas tank. b) Oxygen Tank reduced oxygen consumption by mitochondria respiration inhibition and increased oxygen supply by PFC to achieve synergistic hypoxia regulation. c) Such synergistic hypoxia reversal and Mt-PDT strategy simultaneously supplied exogenous oxygen and inhibited endogenous oxygen consumption to manipulate the tumor hypoxia microenvironment, and ultimately attack the mitochondria of tumor cells

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