Fig. 1
From: P800SO3-PEG: a renal clearable bone-targeted fluorophore for theranostic imaging
Chemical design and optophysical properties of bone-targeted theranostic imaging. a P800SO3-PEG is a bone-targeted heptamethine cyanine fluorophore for NIR-II tail imaging. b Design of P800SO3-PEG using the structure-inherent targeting strategy. c Synthetic routes for bone-targeted agents. d 3D energy minimized chemical structures of the designed fluorophores. e, f Absorbance (Abs) and fluorescence (Fl) spectra of bone-targeted agents in the NIR-1 (e) and NIR-II fluorescence tail imaging (f) recorded for P800SO3-Cl, P800SO3, P800SO3-SH, and P800SO3-PEG (λex = 760 nm) in 10% fetal bovine serum (FBS) solution. g Plasma protein binding assay of bone-targeted NIR fluorophores compared with ICG incubated in 5% bovine serum albumin (BSA)-containing saline for 4 h. h Photothermal effect of bone-targeted NIR fluorophores in PBS (30 µM) under continuous 808 nm exposure for 2 min at a power density of 1.0 W/cm2