Table 2 Common polymeric-derived skin substitutes
From: Evaluating polymeric biomaterials to improve next generation wound dressing design
Product Name | Composition | Classification | ||
|---|---|---|---|---|
Polymer Component(s) | Cellular Component(s) | Clinical Use(s) | Note(s) | |
Dermagraf® | Polyglactin Mesh | Allogeneic Neonatal Fibroblasts (Human) | Burns, Skin Grafting, Chronic Wounds | Improvements in wound healing time and graft success, shown to be less painful and easier to remove than allografts |
Apligraf® | Bilayered Type I Collagen (Bovine) | Allogeneic Keratinocytes (Human) and Allogeneic Neonatal Fibroblasts (Human) | Burns, Skin Grafting, Chronic Wounds, Diabetic Ulcers, Epidermolysis Bullosa | Bilayered living skin equivalent, promotes cellular/tissue ingrowth |
Orcel® | Bilayered Sponge of Type I Collagen (Bovine) | Superficial Allogeneic Keratinocyte Layer (Human) and Deep Allogeneic Fibroblast Layer (Human) | Chronic Wound, Skin Grafting | Bilayered living cellular matrix, often used as an overlay dressing on skin grafts to improve function and cosmesis |
Hyalomatrix® | Bilayered Hyaluronan Scaffold, Outer Silastic Membrane | Autologous Fibroblasts (Human) | Burns, Chronic Wounds | Delivery of hyaluronan to wound bed, with a silicone membrane that acts as a temporary epidermal barrier |
Stratagraft® | Bilayered Type I Collagen (Murine) | Superficial Allogeneic Keratinocyte Layer (Human) and Deep Allogeneic Fibroblast Layer (Human) | Burns, Skin Grafting, Chronic Wounds, Diabetic Ulcers, | Bilayered living skin equivalent, promotes cellular/tissue ingrowth |
Biobrane® | Inner Nylon Mesh, Outer Silastic Membrane, Polypeptide Coating (Porcine) | N/A | Burns, Skin Grafting, Chronic Wounds | Shown to be particularly beneficial for pediatric populations |
Integra® | Collagen (Bovine), Chondroitin-6-Sulphate (Bovine), Outer Silastic Membrane | N/A | Burns, Skin Grafting, Chronic Wounds, Other Soft Tissue Defects | Outer silastic membrane can peel away as dermis heals. Superior healing time relative to auto-/allo-/xeno-grafts |
Matriderm® | Matrix of Type I Collagen (Bovine) and Elastin (Bovine) | N/A | Burns, Skin Grafting, Chronic Wounds | Matrix is structurally intact and promotes cellular/tissue ingrowth |