Fig. 8
From: Evaluating polymeric biomaterials to improve next generation wound dressing design
Bulk versus surface erosion dynamics. A Depiction of polymer structure (grey circle) that contains small molecules (red circles) within the polymeric structure. (Top) Demonstration of bulk erosion and more rapid burst release of small molecules due to the rate of solvent absorption being greater than polymer degradation, relatively. (Bottom) Demonstration of surface erosion and a more gradual controlled release of small molecules due to the rate of degradation being greater than solvent absorption, relatively. B Graphical representation of polymeric dressing properties and drug/small molecular release kinetics over time via Bulk (left) and Surface (right) erosion. Changes in polymer properties depicted in blue lines. Changes in drug release kinetics depicted by red line. C Schematic to represent the relative role of ROS compounds in wound healing. Created using www.biorender.com software