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Table 3 A comparison of major methods for the synthesis of CaPs [20, 28]

From: Biomineralization of bone tissue: calcium phosphate-based inorganics in collagen fibrillar organic matrices

Methods

Advantages

Disadvantages

Precipitation

- Simple setup

- Low operating temperature

- Convenient doping with other ions

- Uniform structures

- High production yield of pure product

- Poor crystallinity

- Irregularly formed

- Inhomogeneous in composition

- Calcium deficient

Hydrothermal

- Good crystallinity

- Convenient doping with other ions

- Hierarchical structure

- Energy consumption

- Low production yield of pure product

Sol–gel

- High homogeneity

- High purity

- Lower processing temperature

- Expensive raw materials

- Difficulty of hydrolysis rate control

- Long processing time

- Cycles depending on sol viscosity

  1. There are some other synthesis methods including high gravity, methods high-temperature pyrolysis, mechanochemical, microwave-assisted synthesis, precursor transformation, solution combustion, sonochemical synthesis, and spray pyrolysis