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Table 2 In vivo study at different time point

From: Peripheral nerve defects repaired with autogenous vein grafts filled with platelet-rich plasma and active nerve microtissues and evaluated by novel multimodal ultrasound techniques

In vivo study (time point)

Treatment

Vein graft

Target muscle (Triceps surae muscle)

2 weeks

High-frequency ultrasound (n = 8 animals/group)

–

CEUS (n = 3 animals/group)

qRT-PCR (VEGF) (n = 3 animals/group)

4 weeks

(n = 4 animals/group)

H&E staining

–

Immunofluorescence staining (S100, NF200)

12 weeks

Nerve function (n = 8 animals/group)

High-frequency ultrasound (n = 8 animals/group)

High-frequency ultrasound (n = 8 animals/group)

SWE and AngioPLUS examinations

(n = 8 animals/group)

Macroscopic evaluation (n = 8 animals/group)

CEUS (n = 5 animals/group)

Electrophysiological recovery evaluation

(n = 5 animals/group)

Macroscopic evaluation (n = 5 animals/group)

Morphometrical evaluation (Electron microscope)

(n = 5 animals/group)

Morphometrical evaluation (H&E, Masson staining)

(n = 5 animals/group)