Table 10 Toxicity data, 4 h exposure, with metabolic activation
From: ISO 10993 biological evaluation of novel hemostatic powder – 4SEAL®
Sample | Number of cells seeded (*10^5) | Number of cells 24 h after treatment (*10^5) | Number of cells 48 h after treatment (*10^5) | Total suspension growth | Relative Suspension Growth (RSG) [%] | Plating Efficiency [%] | Relative Plating Efficiency (RPE) [%] | Relative Total Growth (RTG) [%] |
|---|---|---|---|---|---|---|---|---|
NC1 | 3 | 10.23 | 9.12 | 15.55 | 100.00 | 103.91 | 100.00 | 100.00 |
NC2 | 3 | 9.89 | 9.21 | 15.18 | ||||
PC | 3 | 8.67 | 7.27 | 10.51 | 68.37 | 61.30 | 59.00 | 40.33 |
4SEAL® 1 | 3 | 9.78 | 8.93 | 14.56 | 94.73 | 86.64 | 92.58 | 87.70 |
4SEAL® 2 | 3 | 9.83 | 9.01 | 14.76 | 96.07 | 84.09 | 89.86 | 86.32 |