Fig. 6

(a) Photographs of the back of a mouse over time following the SNP500 extract administration. (b) Thickness and (c) mass of the pinna of the mouse six days after the extract was applied on it (n = 5; **P < 0.01; ***P < 0.001). (d) Relative proliferation of lymphocytes (absorbance at 370 nm, A370 nm) after administering the extract (n = 5; ****P < 0.0001). There was no apparent erythema reaction or physical change when the extract was applied to the mouse, which indicates that SNP500 is highly biocompatible. Photographs of the newly formed bone tissue around (e) cBGM and (f) SNP500 12 weeks after implantation. The damaged parts were filled completely with newly formed bones around both samples. However, the average length of the bone around SNP500 was larger than that of the bone around cBGM. NB, newly formed bone; BM: bone marrow; Ca-P: implanted cBGM and SNP; PP: polypropylene