Fig. 16From: Recent trends in therapeutic application of engineered blood purification materials for kidney diseaseRenal clearable nanochelators to treat secondary hemochromatosis. a Nanochelators are composed of multiple DFO moieties conjugated on renal clearable EPL backbone to minimize nonspecific uptake into immune-related organs, while efficiently capturing plasma iron and being cleared exclusively by the kidneys. b Synthetic scheme of renal clearable DFO-NPs. m represents the number of DFO moieties conjugated on EPL. NIR fluorescent ZW800-1C (green color) was conjugated to track the fate of nanochelators in the body. Reproduced with permission [106]. Copyright 2019, Springer NatureBack to article page