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Fig. 7 | Biomaterials Research

Fig. 7

From: Combinatorial nanococktails via self-assembling lipid prodrugs for synergistically overcoming drug resistance and effective cancer therapy

Fig. 7

Schematic of the nanococktail assembled from small-molecule prodrugs for intratumoral delivery and intranuclear synergistic mechanism to overcome chemoresistance. After intravenous administration, NC extravasates into the tumor and can be effectively internalized by cancer cells. Therapeutically active drugs can be released from the NC and enter the nucleus to poison DNA. Platinum (II) monotherapy is inefficient to cause DSBs due to Rad51-mediated DNA repair. Additional SN38 therapy is anticipated to induce extensive DSBs and provoke robust apoptosis by depleting the repair protein through the ATM/Chk2/p53 axis, leading to optimal efficacy against drug-resistant NSCLC

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Biomaterials Research

ISSN: 2055-7124

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