Table 2 Characters of aptamers conjugated with drugs
From: Design and clinical developments of aptamer-drug conjugates for targeted cancer therapy
Aptamer | Type | Target | Conjugated drug | References |
|---|---|---|---|---|
P19 | RNA | PDAC | Monomethyl auristatin E, 5-fluorouracil, gemcitabine | Yoo et al. (2017), Sora et al. (2016) |
Sgc8 | DNA | PTK7 | Doxorubicin | Yu-Fen et al.(2009) |
AS1411 | DNA | Nucleolin | Doxorubicin, paclitaxel, triptolide | Thu et al. (2015), Fangfei et al. (2017) |
A10 | RNA | PSMA | Doxorubicin, | Vaishali et al. (2006) |
Her2 aptamer | RNA | Her2 | DM1(mertansine) | Hwa et al. (2020) |