Fig. 10
From: Recent trends in therapeutic strategies for repairing endometrial tissue in intrauterine adhesion
A construct of exosomes and collagen scaffolds (CS/Exos) and its ability to regenerate endometrium [108]. (A) Representative transmission electron microscopy (TEM) image. (B) Size distribution profile of exosomes derived from umbilical cord mesenchymal stem cells (UC-MSCs). (C) Western blot analysis of CD63, TSG101, and GRP94 in exosomes (Exos), UC-MSCs and exosome-free conditioned medium (Exos-free). (D) Scanning electron microscope (SEM) image of CS/Exos. (E) Representative confocal laser scanning microscopy (CLSM) image of CS/Dil-labelled Exos. (F) The release profile of exosomes from CS/Exos. (G) Schematic diagram of in vivo experiments. (H) Tracing of implanted CS/Exos in vivo by HE staining. Inserts are the corresponding overview pictures at a lower magnification, and the magnified regions are marked with black squares. (I) Tracing of implanted CS/Dil-labelled Exos in vivo by immunofluorescent staining. (J) Morphologies of uteri under different treatments for 30 and 60 days. Reprinted with permission from Ref. [108]