Fig. 6

In vivo bone regeneration of polycaprolactone (PCL), catechin-loaded PCL (PCL-Cat), hADSC transplanted PCL (PCL-hADSC), and Cat-hADSC transplanted PCL (PCL-Cat-hADSC) scaffolds in critical-sized calvarial bone defect mouse model. A Micro-CT images of the defect site have been seen with a scale bar of 1 mm on 8 weeks of post-transplantation. Quantification of bone coverage area (%) and bone volume (%) has been shown in (B) and (C), respectively (n = 10, **p < 0.01 vs. no treatment group; #p < 0.05 and ##p < 0.01 vs. PCL group; +p < 0.05 vs. PCL-Cat group). D Colorized mineral map of the cross-sectioned micro-CT images with scale bar 1 μm. The defect region is indicated with white arrowheads. (E) Goldner’s Trichrome staining of each group (left, 1 mm) with their expanded images (right, 100 μm). Black arrowheads indicate the defect region [96]