Cells | Function | Ref | |
---|---|---|---|
Epidermis |
Keratinocytes Melanocytes Langerhans cells Merkel cells |
Preservation of immune barrier Skin pigmentation Adaptive immune responses Mechanoreceptors |
[55] [56] [57] [58] |
Dermis |
Fibroblasts Mast cells |
Synthesizing and depositing ECM component Immune and inflammatory responses |
[59] [59] |
Hypodermis | Adipocytes | Energy storage, endocrine, nervous, and immune function | [60] |