|
Amin Yavari et al. 2014 [15]
|
rat
|
femur diafyse (= trabecular)
|
cross-cut femur defect d outer = 5 mm, d inner = 1,3 mm, h = 6 mm
|
“AlAcH” (= por Ti (alkali-acid-heat treated))
|
“AnH” (= por Ti; anodized (also acid- and heat-treated))
|
oxidation (electro-chemical treatment)
|
“Maximum torque (N.mm)” mean + SD measured ( [15]; Fig. 8c)
|
12
|
Amin Yavari (at 12 weeks)
|
|
Garcia-Gareta et al. 2014 [16]
|
sheep
|
femur condyle (= trabecular)
|
cylinder d = 9 mm, h = 11 mm
|
“No Cells” (= por Ti + CaP coating (3-15 μm))
|
“With Cells” (= por Ti + CaP coating (3-15 μm) + MSC (Mesenchymal Stem Cells))
|
adding stem cells
|
“Maximum Force (N)” from push-out testsing mean + SD kindly provided by autor
|
6
|
Garcia-Gareta (at 6 weeks)
|
|
Stübinger et al. 2014 [17]
|
sheep
|
pelvis (= trabecular)
|
screw d = 4,1 mm, h = 9 mm
|
“AM” (= “Additive Manufactured”) (=por Ti (CaF grit blasted + acid washed + US cleaned + dryed))
|
“AM-PSD” (= AM + dendron functionalisation”) (= por Ti (CaF grit blasted + acid washed + US cleaned + dryed + psd (Phosphoserine modified dendron coating)
|
adding growth- factors/ drugs/ others
|
“Removal torque values in Nmm” mean + SD reported ( [17], Table 3)
|
2
|
Stübinger (at 2 weeks)
|
|
8
|
Stübinger (at 8 weeks)
|
|
Cohen et al. 2016 [18]
|
rat
|
calvaria onlay (= cortical)
|
cylinder d = 5 mm, h =?
|
“Rough” (=por Ti (CaF grit blasted + acid etched))
|
“DBX” (=por Ti (CaF grit blasted + acid etched) + (Demineralized Bone Matrix) puty)
|
adding bone-matrix
|
“Force at Failure (N)” from pull-out testing mean + SD measured ( [18], Fig. 3h)
|
10
|
Cohen (at 10 weeks)
|
|
Liu et al. 2016 [19]
|
rabbit
|
tibia (= trabecular)
|
cylinder d = 5 mm, h = 6 mm
|
“Simvastatin 0 mg” (=por Ti (US cleaned))
|
“Simvastatin 0,1 mg” (= por Ti (US cleaned) + 0,1 mg/ml simvastatine/poloxamer 407 hydrogel)
|
adding growth- factors/ drugs/ others
|
“Maximum push-in force (N)” mean + SD reported ( [19], Table 4)
|
4
|
Liu 1 (at 4 weeks)
|
|
8
|
Liu 1 (at 8 weeks)
|
|
“Simvastatin 5 mg” (= por Ti (US cleaned) + 0,5 mg/ml simvastatine/poloxamer 407 hydrogel)
|
4
|
Liu 2 (at 4 weeks)
|
|
8
|
Liu 2 (at 8 weeks)
|
|
Xiu et al. 2016 [20]
|
rabbit
|
femur condyl (= trabecular)
|
cylinder d = 5 mm, h = 6 mm
|
“Control” (= por Ti (US cleaned + dried))
|
“MAO” (= por Ti (US cleaned + dryed) + MicroArc Oxidation)
|
oxidation (electro-chemical treatment)
|
“Push out force (N)” mean + SD reported ( [20] section 4 page 10)
|
8
|
Xiu (at 8 weeks)
|
|
Xu et al. 2016 [21]
|
rabbit
|
calvaria (= cortical)
|
cup with porous scaffold on inside d = 5 mm, h = 5 mm
|
“native SLM” (= por Ti; US cleaned)
|
“SLA” (=por Ti; US cleaned + ZrO2 sandblasted + acid etched)
|
mechano-chemical treatment
|
“Maximum force (N) to failure of pull-out test” mean + SD measured ( [21], Fig. 9c)
|
4
|
Xu 1 (at 4 weeks)
|
|
8
|
Xu 1 (at 8 weeks)
|
|
“SAN” (= por Ti; US cleaned + ZrO2 sandblasted + anodized)
|
mechano-chemical treatment
|
4
|
Xu 2 (at 4 weeks)
|
|
8
|
Xu 2 (at 8 weeks)
|
|
“SAH” (=por Ti; US cleaned + ZrO2 sandblasted + alkali heat treated)
|
oxidation (electro-chemical treatment)
|
4
|
Xu 3 (at 4 weeks)
|
|
8
|
Xu 3 (at 8 weeks)
|
|
Bandyopadhyay et al., 2017 [7]
|
rat
|
distal femur (= trabecular)
|
cylinder d = 3 mm, h = 5 mm
|
“LENS™ Porous Ti” (= “Laser Engineered Net Shaping”)
|
“LENS™ Porous Ti-NT” (= por Ti, anodised, forming nanotubes (d = 105 nm, l = 375 nm))
|
oxidation (electro-chemical treatment)
|
“Shear modulus (MPa)” from push-out testing mean + SD reported ( [7]; Table 3)
|
4
|
Bandyopadhyay (at 4 weeks)
|
|
10
|
Bandyopadhyay (at 10 weeks)
|
|
Cheng et al. 2017 [8]
|
rat
|
calvaria onlay (= cortical)
|
block l = 3,5 mm, w = 5 mm h = 2 mm
|
“Porous” (= por Ti (CaF grit blasted+ acid etched))
|
“Porous + DBX” (= por Ti (CaF grit blasted+ acid etched) + Decalcified Bone Matrix))
|
adding bone-matrix
|
“Pull-out force (N)” mean + SD measured ( [8]; Fig. 4)
|
10
|
Cheng (at 10 weeks)
|
|
MacBarb et al. 2017 [9]
|
sheep
|
distal femur (= trabecular)
|
triangular prism d = 7 mm (inscribed core circle) h = 45 mm
|
“AM” (= “Additive Manufactured” por Ti)
|
“AM + HA” (= por Ti + nanocrystalline HA) 20 nm layer)
|
adding Ca-containing layer
|
“Ultimate Shear Strength (MPa)” mean + SD measured ( [9]; Fig. 4a)
|
6
|
MacBarb 1 (at 6 weeks)
|
|
12
|
MacBarb 1 (at 12 weeks)
|
|
“AM + Auto” (= por Ti + autograft)
|
adding bone-matrix
|
6
|
MacBarb 2 (at 6 weeks)
|
|
12
|
MacBarb 2 (at 12 weeks)
|
|
Tanzer et al. 2019 [22]
|
dog
|
femur diafyse (= cortical)
|
cylinder d = 5,2 mm, h = 10 mm
|
“LRM” (= “Laser Rapid Manufacturing” por Ti)
|
“LRM-PA” (= por Ti + precipitated HA (20-70 μm layer))
|
adding Ca-containing layer
|
“Mean shear strength (Mpa) from push-out testingmean + 95% CI reported ( [22]; results- section, page 3)
|
4
|
Tanzer 1 (at 4 weeks)
|
|
12
|
Tanzer 1 (at 12 weeks)
|
|
“LRM-PSHA” (= por Ti + plasma sprayed HA (20 μm layer))
|
4
|
Tanzer 2 (at 4 weeks)
|
|
12
|
Tanzer 2 (at 12 weeks)
|
|
Teng et al. 2019 [23]
|
rabbit
|
calvaria (= cortical)
|
cylinder d = 20 mm, h = 2 mm
|
“MAO” (= por Ti (sandblasted, acid etched, cleaned, dried) + MicroArc Oxidation)
|
“MAO-CaP” (= por Ti (sandblasted, acid etched, cleaned, dried) + MAO + CaP
|
adding Ca-containing layer
|
“Torsion force (N/cm)” mean + SD reported ( [23], Fig. 6)
|
6
|
Teng 1 (at 6 weeks)
|
|
12
|
Teng 1 (at 12 weeks)
|
|
“MAO-BMP” (= por Ti (sandblasted, acid etched, cleaned, dried) + MAO + CaP + BMP2
|
adding growth- factors/ drugs/ others
|
6
|
Teng 2 (at 6 weeks)
|
|
12
|
Teng 2 (at 12 weeks)
|
|
Bai et al. 2020 [24]
|
rabbit (OVX)
|
distal femur (= trabecular)
|
cylinder d = 6 mm, h = 10 mm
|
“S” (= “Scaffold” = por Ti (US cleaned))
|
“SG” (= por ti (US cleaned) + hydrogel)
|
adding growth- factors/ drugs/ others
|
“Push-out force (N)” mean + SD measured ( [24] Fig. 6c)
|
12
|
Bai 1 (at 12 weeks)
|
|
“SGC” (= por ti (US cleaned) + hydrogel + stem cells)
|
adding stem cells
|
12
|
Bai 2 (at 12 weeks)
|
|
“SGB” (= por ti (US cleaned) + hydrogel + BMP2
|
adding growth- factors/ drugs/ others
|
12
|
Bai 3 (at 12 weeks)
|
|
“SGCB” (= por ti (US cleaned) + hydrogel + stem cells + BMP2)
|
adding stem cells
|
12
|
Bai 4 (at 12 weeks)
|
|
Fan et al. 2020 [25]
|
rabbit
|
radius (= trabecular)
|
cylinder d = 5 mm, h = 13 mm
|
“pTi” (= por Ti)
|
“BaTiO3/pTi (= porTi + BaTiO3 piezoelectric coating)
|
adding growth- factors/ drugs/ others
|
“Peak pull out load (N)” mean + SD measured ( [25] Fig. 11c)
|
6
|
Fan 1 (at 6 weeks)
|
|
12
|
Fan 1 (at 12 weeks)
|
|
“pTi + LIPUS” (= por Ti + Low-Intensity Pulsed Ultrasound treatment)
|
6
|
Fan 2 (at 6 weeks)
|
|
12
|
Fan 2 (at 12 weeks)
|
|
“BaTiO3/pTi” (= porTi + BaTiO3 coating + Low-Intensity Pulsed Ultrasound treatment)
|
6
|
Fan 3 (at 6 weeks)
|
|
12
|
Fan 3 (at 12 weeks)
|
