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Table 2 Retention of 67Ga Labelled MS in Rabbit Livers with and without Implants of VX2 tumours

From: In vivo tumour imaging employing regional delivery of novel gallium radiolabelled polymer composites

Organ Test MS Diameter
[μm]
No. of Tests Lungs
[%Total]
Liver
[%Total]
Body
[%Total]
Normal Liver 30 3 0.07 ± 0.03 98.9 ± 0.3 0.97 ± 0.23
8 2 0.57 ± 0.35 95.2 ± 2.4 4.1 ± 2.0
Soluble 2 4.7 ± 0 15.4 ± 3.0 78.1 ± 3.2
VX2 Liver 30 2 0.02 ± 0.03 99.2 ± 0.2 0.78 ± 0.18
8 4 0.62 ± 0.07 95.7 ± 0.5 3.5 ± 0.5
Soluble 2 1.83 ± 0.13 4.5 ± 1.0 93.1 ± 0.95
  1. Polystyrene sulfonate MS (15 mg, 30 μm and 8 μm median diameter) were radiolabelled with 67Ga (avg. 110 MBq) using TA immobilisation. Suspensions of the MS in 5% dextrose (5 mL) were instilled into the hepatic artery of anaesthetised rabbits. Instillation of soluble 67Ga (avg. 110 MBq) was also performed to provide a comparison of the biodistribution. The rabbits were euthanized after 1 h for dissection and gamma camera imaging of lungs, liver, and body. The activities of all images were corrected for background and the activity of each organ expressed as a percentage of the total activity. Note pronounced liver retention of radiolabel using both 67GaTA-MS30 and 67GaTA-MS8 compared to liver retention of soluble 67Ga. Retention of microsphere radiolabel in livers with VX2 tumour implants was indistinguishable from retention by normal livers