Isotope Form | No. of Tests | Lungs [%Total] | Liver [%Total] | Body [%Total] |
|---|
MS30 | 5 | 97.3 ± 0.4 | 0.61 ± 0.1 | 2.5 ± 0.3 |
MS8 | 3 | 91.1 ± 0.4 | 1.5 ± 0.3 | 7.3 ± 0.7 |
Soluble | 2 | 5.3 ± 0.4 | 9.9 ± 0.7 | 83.4 ± 0.3 |
- Polystyrene sulfonate MS (15 mg, 30 μm and 8 μm median diameter) were radiolabelled with 67Ga (avg. 87 MBq) using TA immobilisation. Suspensions of the MS in 5% dextrose (5 mL) were injected intravenously (ear vein) into anaesthetised rabbits. Intravenous injection of soluble 67Ga (avg. 87 MBq) was also performed to provide a comparison of the biodistribution. The rabbits were euthanized after 3 h for dissection and gamma camera imaging of lungs, liver, and body. The activities of all images were corrected for background and the activity of each organ expressed as a percentage of the total activity
