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Table 1 Leach Tests for 67Ga Labelled MS in Rabbit Lungs

From: In vivo tumour imaging employing regional delivery of novel gallium radiolabelled polymer composites

Isotope Form No. of Tests Lungs
[%Total]
Liver
[%Total]
Body
[%Total]
MS30 5 97.3 ± 0.4 0.61 ± 0.1 2.5 ± 0.3
MS8 3 91.1 ± 0.4 1.5 ± 0.3 7.3 ± 0.7
Soluble 2 5.3 ± 0.4 9.9 ± 0.7 83.4 ± 0.3
  1. Polystyrene sulfonate MS (15 mg, 30 μm and 8 μm median diameter) were radiolabelled with 67Ga (avg. 87 MBq) using TA immobilisation. Suspensions of the MS in 5% dextrose (5 mL) were injected intravenously (ear vein) into anaesthetised rabbits. Intravenous injection of soluble 67Ga (avg. 87 MBq) was also performed to provide a comparison of the biodistribution. The rabbits were euthanized after 3 h for dissection and gamma camera imaging of lungs, liver, and body. The activities of all images were corrected for background and the activity of each organ expressed as a percentage of the total activity