Fig. 4

SPECT-CT of rabbits with VX2 liver tumours using ⁶⁷Ga labelled MS. Polystyrene sulfonate MS (40 mg, 30 μm and 8 μm median diameter) were radiolabelled with ⁶⁷Ga (avg. 110 MBq) using TA immobilisation. The suspensions in 5% dextrose (5 mL) were instilled into the hepatic artery of anaesthetised rabbits bearing VX2 tumour implants in their livers. SPECT-CT imaging of the rabbits was performed 1 h post-injection using a GE Hawkeye Infinia SPECT/CT camera. Hybrid SPECT-CT summary views are shown for ⁶⁷GaTA-MS30 (a) and ⁶⁷GaTA-MS8 (b). In (a) note the ⁶⁷GaTA-MS30 apparent at the tumour site in the liver’s right lobe (left side of the coronal image and left side of the transaxial image), but significant activity also apparent in the rest of the liver. In (b), the ⁶⁷GaTA-MS8 shows more selective accumulation of radioactivity at the tumour site in the implanted lobe, with only low activity in the rest of the liver