Fig. 3
From: In vivo tumour imaging employing regional delivery of novel gallium radiolabelled polymer composites
Retention of 67Ga labelled MS in normal rabbit livers. Polystyrene sulfonate MS (40 mg, 30 μm and 8 μm median diameter) were radiolabelled with 67Ga (avg. 110 MBq) using TA immobilisation. The suspensions in 5% dextrose (5 mL) were instilled into the hepatic artery of anaesthetised rabbits and planar images of excised livers were made 1 h post-injection using a GE Hawkeye Infinia SPECT/CT camera with a medium energy collimator and scatter correction. Soluble 67Ga citrate (avg. 110 MBq) was instilled into hepatic arteries of control rabbits for comparison with the retention of microspheres. Note the prominent vessel features and less extensive volume filling of the liver obtained with 67GaTA-MS30 (a), compared to the more extensively dispersed fine network obtained with 67GaTA-MS8 (b). Under the same conditions, soluble 67Ga citrate was mostly purged from the liver by the normal blood perfusion (c)