Fig. 1

Radiolabelling method for polymer MS. a Step by step scheme for the preparation of ⁶⁷GaTA-MS, starting from an example amount of 50 mg of sulfonated polystyrene MS. b Optimised radiolabelling binding efficiency of ⁶⁷Ga on both 8 μm and 30 μm diameter MS (n = 12, n = 5, respectively. Data combined). The bound fraction of each isotope loading is shown after the initial binding step (Binding), after the step with TA treatment (Fixed) and after autoclaving (Autoclaved); c A comparison of unoptimized microsphere radiolabelling binding efficiency for five different radionuclides. Polystyrene sulfonate MS (50 mg, 30 μm median diameter) was radiolabelled with (columns from left to right) ⁶⁷Ga (100–200 MBq; n = 14), In-111 (34 MBq; n = 2), Tl-201 (93 MBq; n = 2), Lu-177 (50–150 MBq; n = 7) and Y-90 (42 MBq; n = 2). The bound fraction of each radionuclide loading is shown after the initial binding step (Binding), after the step with TA treatment (Fixed) and after autoclaving (Autoclaved)