Fig. 3
From: Biomaterial-based cell delivery strategies to promote liver regeneration
Recellularized liver ECM scaffolds conjugated with homogenized liver ECM promote HepG2 cell proliferation and liver-specific function following transplantation into the mouse liver. a Whole liver, H&E, and ultramicroscopic images of decellularized liver scaffold (DLS) with and without conjugated liver ECM (Conj-DLS). Conj-DLS had more ECM and thicker collagen fibres compared to the DLS. b Semi-quantitative analysis of Ki67+ cells in DLS and conj-DLS demonstrating higher number of Ki67+ cells in conj-DLS compared to DLS. c Representative immunofluorescent images and analysis of ALB, CK19, and HGF expression after hepatic transplantation. I = implanted tissue, s = surrounding liver. Scale bar = 100 μm. Adapted with permission from Ref [189]