Table 3 Nanosuspensions modified as powder dosage forms for oral administration
From: Emerging role of nanosuspensions in drug delivery systems
Types of powder dosage forms | Drug | Conversion method | Comment | References |
|---|---|---|---|---|
Oral Powders | Cefixime | Cospraying with carrier, sorbitol | Solubility of cefixime is 5 fold than coarse powder | [2] |
Oral Powders | Itraconazole | Freeze drying with microcrystalline cellulose | Faster dissolution with increasing amount of MCC | [75] |
Oral Powders | Naproxen, Novartis Compound A | Spray granulation with mannitol | Top spray yielded finer, redispersable particles; No differences in AUC | [16] |
Oral Powders | Rutin | Freeze drying and Spray drying sodium tripolyphosphate and Chitosan | Significant increase in particle size by both methods | [68] |
Inhalable Powders | Ibuprofen | Spray drying with mannitol and/or leucine | Fine particle fraction dependent on both the leucine and mannitol to drug ratio (p < 0.05) | [52] |
Inhalable Powders | Niclosamide | Spray drying with mannitol | Strong quorum sensing inhibiting activity against Pseudomonas aeruginosa | [12] |