Table 2 Physical characterization tests and methods
From: Emerging role of nanosuspensions in drug delivery systems
Parameters | Methods |
|---|---|
Particle-size distribution (during preparation, transportation and accelerated stability conditions) | Photon correlation spectroscopy, transmission electron microscopy, scanning electron microscopy, atomic force microscopy, scanning tunneling microscopy, or freeze fracture electron microscopy |
Surface potential | Laser doppler anemometry, Zeta potential meter |
Surface hydrophobicity | Contact angle goniometry, Hydrophobic interaction chromatography |
Surface analysis | Static secondary ion mass spectrometry |
Crystalline state and amorphous state | X-ray diffraction analysis supported by differential scanning calorimetry scanning electron microscopy, atomic force microscope or transmission electron microscopy |
Syringeability and injectability | Texture analyzer |
Drainability | Freeness tester |
Redispersibility | Powder tester |
Solubility | Equilibrium solubility method, Kinetic solubility method |
Dissolution | Dissolution test apparatus |