TY - JOUR AU - González-Masís, Jeimmy AU - Cubero-Sesin, Jorge M. AU - Guerrero, Simón AU - González-Camacho, Sara AU - Corrales-Ureña, Yendry Regina AU - Redondo-Gómez, Carlos AU - Vega-Baudrit, José Roberto AU - Gonzalez-Paz, Rodolfo J. PY - 2020 DA - 2020/11/23 TI - Self-assembly study of type I collagen extracted from male Wistar Hannover rat tail tendons JO - Biomaterials Research SP - 19 VL - 24 IS - 1 AB - Collagen, the most abundant protein in the animal kingdom, represents a promising biomaterial for regenerative medicine applications due to its structural diversity and self-assembling complexity. Despite collagen’s widely known structural and functional features, the thermodynamics behind its fibrillogenic self-assembling process is still to be fully understood. In this work we report on a series of spectroscopic, mechanical, morphological and thermodynamic characterizations of high purity type I collagen (with a D-pattern of 65 nm) extracted from Wistar Hannover rat tail. Our herein reported results can be of help to elucidate differences in self-assembly states of proteins using ITC to improve the design of energy responsive and dynamic materials for applications in tissue engineering and regenerative medicine. SN - 2055-7124 UR - https://doi.org/10.1186/s40824-020-00197-0 DO - 10.1186/s40824-020-00197-0 ID - González-Masís2020 ER -