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Fig. 8 | Biomaterials Research

Fig. 8

From: In vivo bone regeneration assessment of offset and gradient melt electrowritten (MEW) PCL scaffolds

Fig. 8

IHC analysis of Alp in calvarial defects from rats 4 and 8 weeks post-implantation of MEW PCL scaffolds. a) Blank (defect control without implanted scaffold), 250 μm, 500 μm. b) Offset.50.50, Grad.750top, Grad.250top. Alp: alkaline phosphatase staining, Iso: Isotype control. The white bar represents 200 μm. c) Quantitative analysis at weeks 4 and 8. The values expressed are the mean ± SD (n = 3). Statistically significant differences between mean Alp intensity scores for the treatment groups when compared to each other were determined by ANOVA (Significant: * p < 0.0001, ^ p = 0.002, ■ p < 0.0001, ♦ p = 0.002, p = 0.001, p = 0.009)

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