Fig. 7
From: In vivo bone regeneration assessment of offset and gradient melt electrowritten (MEW) PCL scaffolds
IHC analysis of Col I in calvarial defects from rats 4 and 8 weeks post-implantation of MEW PCL scaffolds. a) Blank (defect control without implanted scaffold), 250 μm, 500 μm. b) Offset.50.50, Grad.750top, Grad.250top. Col: collagen type I staining, Iso: Isotype control. The white scale bar represents 200 μm. c) Quantitative analysis of Col I staining at weeks 4 and 8. The values expressed are the mean ± SD (n = 3). Statistically significant differences between mean Col I intensity scores for the treatment groups when compared to each other were determined by ANOVA (Significant: * p ≤ 0.0001, ^ p = 0.004, ■ p ≤ 0.0001, ♦ p = 0.002, ▼p = 0.002, ● p ≤ 0.0004)