Fig. 5
From: Therapeutic efficacy of nanoparticles and routes of administration
CNT functionalization for siRNA delivery. To achieve an effective siRNA delivery, CNTs were functionalized with covalent and non-covalent crosslinking. a CNT covalently linked with cationic polymer polyethylenimine (PEI) b CNT functionalized with non-covalent interaction with cationic cetylpyridinium. The different functionalization methods were tried to achieve efficient gene silencing. A thin and long structural feature of CNT offers long surface area and nano-needle morphology facilitates easy translocation over the plasma membrane via endocytosis-independent pathway