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Table 1 Overview of the characteristics of PDMS breast implant surface modification methods

From: Silicone breast implant modification review: overcoming capsular contracture

Modification Methods Type Characteristics
Roughness Modification Smooth Severe fibrosis, High CC incidence rate
Textured Surface roughness of 100–300 μm, Fixing of the implant position, Known to cause less fibrosis, ALCL
Micro Textued Surface roughness of 10 to 100 μm, Low CC incidence rate
Anti- adhesion barrier solution (AABS) treatment Reducing inflammation and fibrosis formation
Anti-bacterial Lower the incidence of CC
Plasma treatment Increased wettability, Easy to functionalize
Anti-fibrosis drug coating Triamcinolone Glucocorticoids, Effectively suppress fibrosis and CC, Cause side effects
Tranilast Drug that targets TGF-β, Suppress fibrosis and CC
Montelukast/zafirlukast Inhibitors of Cysteinyl leukotriene (CysLTs), Suppress fibrosis and CC
Halofuginone Interferes with Smad3 phosphorylation in the TGF-β signaling pathway, Cause side effects, Suppress fibrosis and CC