Table 1 Overview of the characteristics of PDMS breast implant surface modification methods
From: Silicone breast implant modification review: overcoming capsular contracture
Modification Methods | Type | Characteristics |
|---|---|---|
Roughness Modification | Smooth | Severe fibrosis, High CC incidence rate |
Textured | Surface roughness of 100–300 μm, Fixing of the implant position, Known to cause less fibrosis, ALCL | |
Micro Textued | Surface roughness of 10 to 100 μm, Low CC incidence rate | |
Anti- adhesion barrier solution (AABS) treatment | • | Reducing inflammation and fibrosis formation |
Anti-bacterial | • | Lower the incidence of CC |
Plasma treatment | • | Increased wettability, Easy to functionalize |
Anti-fibrosis drug coating | Triamcinolone | Glucocorticoids, Effectively suppress fibrosis and CC, Cause side effects |
Tranilast | Drug that targets TGF-β, Suppress fibrosis and CC | |
Montelukast/zafirlukast | Inhibitors of Cysteinyl leukotriene (CysLTs), Suppress fibrosis and CC | |
Halofuginone | Interferes with Smad3 phosphorylation in the TGF-β signaling pathway, Cause side effects, Suppress fibrosis and CC |