Fig. 14From: Layer-by-layer assembled polymeric thin films as prospective drug delivery carriers: design and applicationsHyaluronan Layer-by-Layer (LbL) nanoparticles actively target the hypoxic, low pH tumor by binding to the cancer stem cell receptor CD44. a Schematic illustrating bimodal tumor-targeted delivery. b Polycation and c Polyanion components of the LbL nanoparticle. CD44 protein structure in (a) is rendered from biological assembly 1 of PDB ID 1UUH. (Reprinted with permission from Ref. [75]. Copyright 2014, American Chemical Society)Back to article page