Fig. 5From: Schwann cell durotaxis can be guided by physiologically relevant stiffness gradientsOverlaid cell boundaries from representative migrating Schwann cells on either a uniform or b steep gradient substrates. Left corresponds to earlier and right corresponds to later captured images and cell silhouettes are temporally color coded with cell shape demarcated in lighter grays for earlier time points and black for later time points. Frame interval is 2 hours. On the uniform substrate (4325 Pa), cell motion is random and morphology is dynamically sporadic, switching back and forth from a bipolar morphology to a more circular keratocyte-like shape. On the steep gradient substrate (190 - 4325Pa), note the increase in cell spread area and elongation, which is oriented along the direction of increasing stiffness on the rigidity gradient. Morphologic complexity is present throughout the duration of the timelapse. Boxed image: superimposed images from sequence at left. Scale bar represents 100 μmBack to article page