TY - JOUR AU - Jeon, Jin AU - Lee, Min Suk AU - Yang, Hee Seok PY - 2018 DA - 2018/02/23 TI - Differentiated osteoblasts derived decellularized extracellular matrix to promote osteogenic differentiation JO - Biomaterials Research SP - 4 VL - 22 IS - 1 AB - The extracellular matrix (ECM) can directly or indirectly influence on regulation of cell functions such as cell adhesion, migration, proliferation and differentiation. The cell derived ECM (CD-ECM) is a useful in vitro model for studying the comprehensive functions of CD-ECM because it maintains a native-like structure and composition. In this study, the CD-ECM is obtained and a test is carried out to determine the effectiveness of several combinations of decellularized methods. These methods were used to regulate the optimal ECM compositions to be induced by osteogenic differentiation using primary isolated osteoblasts. SN - 2055-7124 UR - https://doi.org/10.1186/s40824-018-0115-0 DO - 10.1186/s40824-018-0115-0 ID - Jeon2018 ER -