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Fig. 6 | Biomaterials Research

Fig. 6

From: Calcium phosphates and silicon: exploring methods of incorporation

Fig. 6

Expression of osteogenic markers at mRNA level of hMSC seeded on CaP-A, CaP-I with 0, 1, 5 and 10 mM of Si and CaP-M with 0, and 1 mM of Si after 3, 7 and 14 days. OM represents the condition in which the cells were cultured on CaP coatings in osteogenic medium. Significant differences among the same condition analyzed at different time points are indicated by asterisks. Connector lines indicate the significant differences between different conditions at the same time point. (p < 0.05; n = 6). RUNX2 expression was significantly higher in CaP-I 10 mM than in the other conditions at 7 days of culture. BMP2 was up-regulated in CaP-A and CaP-I 5 and 10 mM as well as for CaP-M in osteogenic medium. Similar behavior was found for OC. OP was significantly up-regulated in both CaP-A and CaP-I 10 mM, a slight increase was also observed for Ca-A and CaP-I 5 mM. All conditions presented an up-regulation of the studied genes from day 7 to day 14

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