Table 4 Downregulated genes differentially expressed in the liver tissue of aged rats
From: Anti-aging effect and gene expression profiling of dung beetle glycosaminoglycan in aged rats
| Â | CaG5 | IQG5 | CS10 | Description | Gene Symbol |
|---|---|---|---|---|---|
1 | 0.13 | 0.35 | 0.20 | lysyl oxidase | Lox |
2 | 0.19 | 0.53 | 0.75 | similar to Spindlin-like protein 2 (SPIN-2) | LOC367746 |
3 | 0.24 | 0.42 | 0.90 | serine dehydratase | Sds |
4 | 0.28 | 0.24 | 0.63 | cytokine inducible SH2-containing protein | Cish |
5 | 0.29 | 0.64 | 0.65 | retinol saturase (all trans retinol 13,14 reductase) | Retsat |
6 | 0.35 | 0.45 | 0.62 | similar to hypothetical protein MGC42105 | RGD1308116 |
7 | 0.36 | 0.28 | 0.39 | solute carrier family 25, member 30 | Slc25a30 |
8 | 0.36 | 1.01 | 0.39 | aldo-keto reductase family 1, member B7 | Akr1b7 |
9 | 0.37 | 0.19 | 0.26 | one cut homeobox 1 | Onecut1 |
10 | 0.38 | 0.66 | 0.68 | CCR4 carbon catabolite repression 4-like (S. cerevisiae) | Ccrn4l |
11 | 0.38 | 0.62 | 1.58 | patatin-like phospholipase domain containing 3 | Pnpla3 |
12 | 0.38 | 0.49 | 0.95 | myotubularin related protein 7 | Mtmr7 |
13 | 0.39 | 0.18 | 0.26 | one cut homeobox 1 | Onecut1 |
14 | 0.40 | 0.85 | 1.11 | keratin 10 | Krt10 |
15 | 0.40 | 0.99 | 0.85 | cytochrome P450, family 17, subfamily a, polypeptide 1 | Cyp17a1 |
16 | 0.41 | 0.88 | 1.07 | glutamate receptor, ionotrophic, AMPA 3 | Gria3 |
17 | 0.41 | 0.70 | 0.65 | cAMP responsive element modulator | Crem |
18 | 0.41 | 0.96 | 1.46 | glycerol-3-phosphate acyltransferase, mitochondrial | Gpam |
19 | 0.42 | 1.00 | 1.49 | sulfotransferase family, cytosolic, 1C, member 2 | Sult1c2 |
20 | 0.42 | 0.30 | 0.44 | family with sequence similarity 89, member A | Fam89a |
21 | 0.42 | 0.32 | 0.34 | solute carrier family 25, member 30 | Slc25a30 |
22 | 0.42 | 1.20 | 0.98 | integrin, alpha 1 | Itga1 |
23 | 0.45 | 0.73 | 0.80 | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | Got1 |
24 | 0.45 | 1.29 | 1.05 | guanine nucleotide binding protein, alpha 14 | Gna14 |
25 | 0.45 | 0.37 | 0.76 | similar to Urinary protein 3 precursor (RUP-3)///similar to Urinary protein 2 precursor (RUP-2) | LOC68 0367///LO |
26 | 0.46 | 0.81 | 0.74 | similar to Maltase-glucoamylase, intestinal | LOC679818 |
27 | 0.46 | 0.63 | 0.69 | ADAM metallopeptidase domain 8 | Adam8 |
28 | 0.46 | 0.63 | 0.74 | G0/G1switch 2 | G0s2 |
29 | 0.46 | 0.65 | 0.70 | somatostatin receptor 3 | Sstr3 |
30 | 0.46 | 0.58 | 0.69 | cAMP responsive element modulator | Crem |
31 | 0.47 | 0.57 | 0.56 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | Rrs1 |
32 | 0.47 | 0.49 | 0.50 | choline kinase alpha | Chka |
33 | 0.47 | 0.70 | 0.86 | early growth response 1 | Egr1 |
34 | 0.48 | 0.45 | 0.37 | G patch domain containing 4 | Gpatch4 |
35 | 0.48 | 1.15 | 1.11 | similar to ovostatin-2 | RGD1565709 |
36 | 0.48 | 0.42 | 0.66 | regulator of G-protein signaling 3 | Rgs3 |
37 | 0.49 | 0.65 | 0.51 | tsukushin | Tsku |
38 | 0.49 | 0.75 | 1.58 | mesenchyme homeobox 2 | Meox2 |
39 | 0.49 | 0.87 | 0.71 | cyclin D1 | Ccnd1 |
40 | 0.49 | 0.39 | 1.45 | phosphoglycerate dehydrogenase | Phgdh |