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Table 1 List of Lipid-PLGA nanoparticles and applications

From: Lipid-based surface engineering of PLGA nanoparticles for drug and gene delivery applications

Lipid Polymeric core Preparation method Encapsulated Drug Size(nm) Charge(mV) Application Reference
Lecithin/DSPE-PEG PLGA One step Au/QDs 50–60 NA Diagnostic/Optical imaging [32]
Chol Curcumin 203 -0.67 ± 1.23 Cancer therapy [34]
EPC, DOPE-Tf/TPGS Aromatease Inhibitor 150–190 -18 ± 2 Cancer therapy [56]
Lecithin, DMPE,DTPA/DSPE-PEG Docetaxel, 90Y,111In 65 35 Cancer therapy [57]
Lecithin/DSPE-PEG Paclitaxel - Gemcitabine 70 ± 1 -51 ± 2 Cancer therapy [58]
Lecithin/DSPE-PEG Paclitaxel 55 ± 1 NA Treatment of coronary artery disease [59]
DSPE-PEG docetaxel 25 -10 Cancer therapy [60]
EPC DSPE-PEG Two step siRNA 225 ± 8 - 10 Gene Delivery [61]
FA-QLCS,Chol, PEG-OQLS Paclitaxel 184 ± 7 22 ± 4 Targeted nanoparticle for cancer therapy [62]
Chol, DOTAP, DSPE-PEG BSA ~144 +4–6 Vaccine delivery [63]
DOPC,DOTAP, DSPE-PEG One step Sirolimus 174 ± 9.6 −14 ± 0.3 Sustained antiproliferative therapy for the treatment of restenosis [13]
Propolis 183 ± 13.7 −21 ± 2.08
DOTAP Sirolimus 201 ± 10.3 36 ± 6.5
Propolis 205 ± 9.4 14 ± 4.1
DOPC Sirolimus 201 ± 8.8 −24 ± 1.2
Propolis 212 ± 11 −32 ± 2.5
DOPC,DOTAP Sirolimus 186 ± 8.6 −12 ± 3.5
Propolis 194 ± 11.7 −19 ± 2.4
DOTAP (6 %) One step pDNA 209 ± 10.4 36 ± 5.4 Gene delivery [15]
DOTAP (12 %) 186 ± 7.9 49 ± 2.3
DOTAP (18 %) 163 ± 5.6 57 ± 2.5
DOTAP (24 %) 154 ± 5.2 64 ± 3.2
RBC membranes Two step Doxorubicin 70–90 -10 ± 2.7 Long circulating carrier [44]
Platelet membranes Docetaxel 113.4 ± 1.2 -29.5 ± 1.2 Natural targeted drug delivery. Long circulating carrier [26]
Vancomycin 200.3 ± 3.1 -30.2 ± 1.0
Cancer cell membranes NA ~110 -35 ± 5 Natural cancer targeted drug delivery. Whole cell cancer vaccine [64]
Monocyte membranes Doxorubicin ~150–180 −16.5 Natural cancer targeted drug delivery [14]
Adipose derived Stem cell membranes VEGF 100–150 -15 ± 1.3 Natural targeted drug delivery. Stem cell mimetic nanocarrier [12]