Fig. 3
From: Multiple genetically engineered humanized microenvironments in a single mouse
Comparison of tissue formation between growth-competent and growth-arrested genetically engineered stromal cells seeded scaffolds. a Gross image of explanted scaffolds with growing genetically engineered stromal cells 6 weeks after implantation, and (b) Diameters of explanted scaffolds (N = 5, *P < 0.05). c Gross image of explanted scaffolds with growth arrested genetically engineered stromal cells 6 weeks after implantation (Scale bar = 5 mm). d-e Comparison of hematoxylin and eosin stained tissue sections between growth-competent and growth-arrested engineered stromal cell-seeded scaffolds. d Growth-competent stromal cells compactly filled with fibroblastic cells. e Growth-arrested stromal cells formed organized tissue microenvironments that accommodate both stromal and hematopoietic components. Both growth competent and growth arrested hTNFa stromal cell-scaffolds showed minimum stromal component and mimicked inflammatory microenvironment. (Scale bar, 200 μm)