Fig. 6
From: Biomimetic substrate control of cellular mechanotransduction
Human MSCs cultured on 12 and 21 nm high nanoislands have increased mechanosensitivity to fluid shear. The percentage of cells responding in intracellular calcium, [Ca2+]i, under fluid shear stimulation. Human MSCs were cultured on nanoisland topographies with varying island heights and flat controls and exposed to shear stresses. *: p < 0.05, **: p < 0.01 compared with flat control (reprinted from Salvi et al. [48] with permission from Elsevier)