Fig. 5
From: Angiogenin-loaded fibrin/bone powder composite scaffold for vascularized bone regeneration
Hematoxylin-eosin-stained image of blood vessel formation in the central area of the calvarial defect site at 2 weeks after implantation. Many blood vessels clearly penetrated into the connective tissue and near the new bone in the FB/ANG 2.0 group. In addition, multinuclear cells and fibroblasts infiltrated into the connective tissue. Asterisk: residual material bone powder, black arrow: blood vessels. Empty: non-treated defect, FB: fibrin glue/bone scaffold alone, FB/ANG 0.5; FB scaffold loaded with 0.5 μg of ANG, FB/ANG 2.0; FB scaffold loaded with 2.0 μg of ANG. Scale bar = 250 μm