Fig. 6From: Guided bone regeneration using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-cross-linked type-I collagen membrane with biphasic calcium phosphate at rabbit calvarial defectsBone formation around EDC membrane at 8Â weeks. (a) EDC membrane group at 8Â weeks showing mature new bone formation within the membrane space. X40 magnification, Hematoxylin & eosin staining.(b) Formation of new bone matrix (NB) by the osteoblasts (arrows) can be seen. New bone is appeared to be maturing into lamellar structures as seen by the appearance of osteocytes and the resulting Haversian system. Newly formed bone is in contact with the membrane structures (CM), which suggests good biocompatibility and tissue integration of the EDC membrane. Formation of transmembraneous blood vessels (BV) can also be seen occurring within the membrane space. X400 magnification, Hematoxylin & eosin staining Back to article page