TY - JOUR AU - Kaushik, Sagar N. AU - Scoffield, Jessica AU - Andukuri, Adinarayana AU - Alexander, Grant C. AU - Walker, Taneidra AU - Kim, Seokgon AU - Choi, Sung Chul AU - Brott, Brigitta C. AU - Eleazer, Paul D. AU - Lee, Jin-Yong AU - Wu, Hui AU - Childers, Noel K. AU - Jun, Ho-Wook AU - Park, Jae-Hong AU - Cheon, Kyounga PY - 2015 DA - 2015/06/01 TI - Evaluation of ciprofloxacin and metronidazole encapsulated biomimetic nanomatrix gel on Enterococcus faecalis and Treponema denticola JO - Biomaterials Research SP - 9 VL - 19 IS - 1 AB - A triple antibiotic mixture (ciprofloxacin; CF, metronidazole; MN, and minocycline; MC) has been used for dental root canal medicaments in pulp regeneration therapy. However, tooth discolorations, cervical root fractures, and inadequate pulp-dentin formation have been reported due to the triple antibiotic regimen. Therefore, an antibiotic encapsulated biomimetic nanomatrix gel was developed to minimize the clinical limitations and maximize a natural healing process in root canal infections. In this study, minimal bacterial concentrations (MBC) of the selected antibiotics (CF and MN) were tested in 14 representative endodontic bacterial species. Then MBC of each CF and MN were separately encapsulated within the injectable self-assembled biomimetic nanomatrix gel to evaluate antibacterial level on Enterococcus faecalis and Treponema denticola. SN - 2055-7124 UR - https://doi.org/10.1186/s40824-015-0032-4 DO - 10.1186/s40824-015-0032-4 ID - Kaushik2015 ER -