Table 6 Rat animal models of osteoradionecrosis
From: New approach for the treatment of osteoradionecrosis with pentoxifylline and tocopherol
| Radiation irradiation | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Animal | Sample | Source | Fraction dose | Frequency | Interval | Total dose | Irradiation target | Intervention | Time after irradiation | Evaluation | Reference |
| SD rats | 12 | Ortho | 5.91/7/8.89 | 5 | 1d | 29.5/35/44.5 | Mandible (Left) | Mechanical test | 56 days | - | Tchanque-Fossuo et al. (2011) [19] |
| SD rats male | 10 | Brachy | 20 | 7d | Mandible (Left) | Extraction | 21 days | Radiology, histology | Tamplen et al. (2011) [35] | ||
| SD rats | 20 | Ortho | 5.91/7/8.89 | 5 | 1d | 29.5/35/44.5 | Mandible (Left) | Histology only | 56 days | Histology | Tchanque-Fossuo et al (2011) [19] |
| SD rats male | 10 | Brachy | 30 | 1 | 30 | Mandible (Left) | Extraction | 28 days | Radiology, histology | Cohen et al. (2011) [41] | |
|
SD rats male | 10 | Ortho | 3.6 | 10 | 1d | 36 | Mandible (Left) | DO unilateral | 8 weeks | Histology | Inyang et al. (2010) [43] |
| Rat | hfSRT | 15 | 60 | Mandible (Left) | DO unilateral | 6,12 weeks | Radiology , histology | Fenner et al. (2010) [40] | |||
| Wistar rats male | 108 | Co60 | 8 | 1 | 8 | Mandible (Left) | Extraction | 10,12 days | Histology | Hosokawa et al. (2007) [44] | |
| SD rats male | 12 | Ortho | 3.6 | 10 | 1d | 36 | Mandible (Left) | DO unilateral | 8 weeks | Radiology | Fregene et al. (2009) [45] |
| Rats (WKY, Lewis, Fisher) male | 24 | Brachy | 20 | 1 | 20 | Mandible (Right) | Injection | 7 weeks | Radiology & histology | Springer et al. (2008) [48] | |
| Rats (WKY, Lewis, Fisher) male | 24 | Brachy | 20 | 1 | 20 | Mandible (Right) | Histology only | 100 days | Histology | Niehoff et al. (2008) [37] | |
| Wistar rats | 25 | 6 MV | 15 | 4 | 2w | 60 | Mandible (Left) | Histology only | 6,12 weeks | Histology | Fenner et al. (2010) [40] |
| Wistar rats male | 30 | Ortho | 6 | 7 | 2 - 3d | 42 | Mandible (Right) | Histology only | 85,141, 253 days | Histology | Williamson R.A (2007) [29] |
| SD rats male | 60 | Co60 | 2.5/3 | 18/15 | 45 | Mandible (Bilateral) | Bone defect | 6, 8 weeks | Histology | Lorente et al. (1992) [46] | |
| SD rats male | 10 | Brachy | 20 | 1 | 20 | Mandible (Left) | Extraction | 28 days | Radiology, histology | Tamplen et al. (2011) [35] | |
| Wistar rats | 50 | Ortho | 20 | 1 | 20 | Mandible (Left) | Growth only | 30, 60 days | Radiology, histology | Ubios et al. (1992) [47] | |