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Fig. 1 | Biomaterials Research

Fig. 1

From: Engineering TGF-β inhibitor-encapsulated macrophage-inspired multi-functional nanoparticles for combination cancer immunotherapy

Fig. 1

Synthesis and physicochemical characterization of MϕNP and Mϕ-SDNP. (A) Fabrication process of Mϕ-SDNP using conventional cell-membrane isolation and sonication. (B) Transmission electron microscopy (TEM) images of PLGA nanoparticles (PLNP) and macrophage-membrane-coated PLGA nanoparticles (MϕNP). Scale bars = 100 nm. (C) Energy-dispersive spectroscopy (EDS) elemental mapping analysis image of MϕNP. Scale bars = 100 nm. (D) EDS total intensity distribution of PLNP and MϕNP. E - F) Quantification of the protein scavenging effect of MϕNP by ELISA. CCR2 or CSF1R blocked MϕNP was represented to CCR2b- or CSF1Rb-MϕNP. (E) Unbound CCL2 level. (F) Unbound CSF1 level. (G) Hydrodynamic size and zeta potential analysis of SD-208-loaded macrophage membrane-coated nanoparticles (Mϕ-SDNP) by DLS. (H) The process of macrophage membrane coating does not affect the drug loading of nanoparticles. Spectrophotometric analysis of SD-208-loaded nanoparticles. (I) In vitro SD-208 release profiles obtained with a microplate reader at a wavelength of 370 nm

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Biomaterials Research

ISSN: 2055-7124

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