Fig. 5

Blood glucose prediction by using measurement of tear glucose levels with the SD strip biosensor. a Touch of SD strip biosensor in the inferior palpebral conjunctiva (IPC) of a diabetic rabbit model. Arrow: SD strip biosensor. b Monitoring surface damage to the eye during tear collection with a glass capillary tube or SD strip biosensor. Eye damage was visualized after instillation into the rabbit IPC with 5 μL of 0.25% w/v fluorescein sodium solution. Fluorescein image: eye damage. Fluorescent region indicates eye tissue damage. c The comparison between the normalized b values and blood glucose concentration at each time point. At each sampling time, five rabbits were tested and a single measurement was performed for each animal. Data were presented as the mean ± standard deviation (n = 5). d The comparison between the tear glucose and blood glucose concentration at each time point. Data were presented as the mean ± standard deviation (n = 5). e A linear correlation between blood and tear glucose levels. Data were presented as the mean ± standard deviation (n = 5). f A linear correlation between blood glucose levels and normalized b values. Data were presented as the mean ± standard deviation (n = 5)