Fig. 2
From: A polymeric nanocarrier that eradicates breast cancer stem cells and delivers chemotherapeutic drugs
HA-b-PCDA as a nanocarrier to deliver chemotherapeutic drugs. (A) The conformation of the complex consisting of HA-b-PCDA with DOX, PTX, DTX, GEM or CPT obtained by the molecular docking study. (B) RMSD value of the complex of HA-b-PCDA and DOX, HA-b-PCDA and PTX, HA-b-PCDA and DTX, HA-b-PCDA and GEM, or HA-b-PCDA and CPT obtained by the molecular dynamics study. (C) The schematic illustration of the method of HA-b-PCDA to encapsulate chemotherapeutic drugs, forming drug-loaded HA-b-PCDA nanoparticles. (D) The hydrodynamic sizes of DOX/HA-b-PCDA NPs (a), PTX/HA-b-PCDA NPs (b), DTX/HA-b-PCDA NPs (c), GEM/HA-b-PCDA NPs (d), CPT/HA-b-PCDA NPs (e), and HA-b-PCDA NPs (f). (E) The zeta potentials of DOX/HA-b-PCDA NPs (a), PTX/HA-b-PCDA NPs (b), DTX/HA-b-PCDA NPs (c), GEM/HA-b-PCDA NPs (d), CPT/HA-b-PCDA NPs (e) and HA-b-PCDA NPs (f). (F) The morphologies of HA-b-PCDA NPs (a) and DOX/HA-b-PCDA NPs (b) observed by TEM