Fig. 5
In vivo photothermally enhanced and synergized nanocatalytic therapy. A Infrared thermography of mice. B Temperature increase at tumor sites of mice. C Tumor growth curves. D Tumor weights on day 14. E Photographs of typically harvested tumors at day 14 after the treatments. F TUNEL and H&E staining of tumor tissues (Scale bar = 50 μm). In C-F), Mice were divided into 4 treatment groups as described in the main text. I: Control (intravenous injection of 200 μL PBS), II: intravenous injection of PBS + Laser irradiation (1064 nm; 1 W/cm2), III: intravenous injection of Mn/N-HCN (1 mg/mL, 200 μL), IV: Intravenous injection of Mn/N-HCN + Laser irradiation. (Statistical analysis was analyzed using Student's t-test for comparison. *P < 0.05, **P < 0.01, ***P < 0.001, n.s. = not significant.)